Intensive course on experimental design and biostatistics

Currently, the scientific literature is critical of the translatability of in vivo research results and of the reproducibility of research conducted with animals. There are certainly solutions on what should be done to improve the translatability and reproducibility of animal experiments.
Among the solutions, statistics and experimental design play a central role to reach better translatability and reproducibility, in addition to contribute to the Reduction arm of the ThreeRs. This course addresses the central question of how to design your experiments and which test to perform given your specific research questions.
This course offers lectures, exercises and discussions on these topics.

From:

29/09/2023

To:

13/10/2023

Language: English
Teaching method:

Online course
Location:

Online

Duration: 3 mornings, 29 September, 6 October, and 13 October 2023
Target audience:

PhD students, postdocs, researchers, lab animal scientists and technicians, and members of Animal Welfare
Bodies.
Contents:

STATISTICS FOR ANIMAL EXPERIMENTS 

Reserch design: 

  • Confouding factors
  • Randomization
  • Blinding
  • Defining outcomes and endpoints

Hypothesis tests: 

  • How to select your statistical test ?
  • One and two-sided tests
  • Pitfalls and caveats in hypothesis testing
  • Multiple testing and p-hacking
  • Student t-test
  • ANOVA

THE EXPERIMENTAL DESIGN: HOW TO GENERALIZE THE RESULTS

How to calculate the «right» sample size:

  • Power calculation
  • Calculating power using simulations
  • Post-hoc power calculation

Experimental design illustrated by practical examples:

  • Randomized, blinded, controlled experiments
  • Formal experimental design: Completely randomized, Randomized complete block, Factorial design, Examples, advantages and limitations
More information:

For further information please contact secretary@fondazioneguidobernardini.org  

 



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